Preserved or enhanced OATP1B3 expression in hepatocellular adenoma subtypes with nuclear accumulation of β-catenin
نویسندگان
چکیده
منابع مشابه
β-catenin activated hepatocellular adenoma
Hepatocellular adenoma (HCA) is a benign liver tumor composed of hepatocytes. HCA represents a heterogeneous entity, and is subclassified into four groups according to genotype and phenotype: hepatocyte nuclear factor (HNF) 1α-inactivated HCA, β-catenin-activated HCA, inflammatory HCA, and unclassified HCA. Theses subtypes vary greatly in their clinical and pathological features. Identifying th...
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background beta catenin plays a key role in cancer tumorigenesis. however, its prognostic significance in patients with colorectal cancer (crc) remains controversial. it has been demonstrated that 90% of all tumors have a mutation in individual components of multiple oncogenes in wnt/β-catenin pathway. accumulation of nuclear β-catenin in cytoplasm leads to uncontrolled cell proliferation. thus...
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Beta-catenin has a dual role in the cell. At the membrane, it connects E-cadherin to the actin cytoskeleton, while in the nucleus, it controls gene expression in concert with Tcf-like transcription factors. Nuclear translocation of beta-catenin is induced by the Wnt signal transduction pathway. Control of this process is essential since elevated beta-catenin levels interfere with differentiatio...
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ژورنال
عنوان ژورنال: Hepatology Research
سال: 2014
ISSN: 1386-6346
DOI: 10.1111/hepr.12453